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1, 7.two) ]. Challenges of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant utilization of Promethazine with Codeine Oral Remedy with all cytochrome P450 2D6 inhibitors (eg., amiodarone, quinidine) may possibly end in an increase in codeine plasma concentrations in addition to a lessen in Energetic metabolite mor